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It's a very rare disease, affecting only about 300 people in the united states annually. Cjd usually appears in later life and runs a rapid course. Sporadic, familial, iatrogenic and variant.

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In the united states there are about 300 cases per year. Cjd usually appears in later life and runs a rapid course. This diseases progresses rapidly and is always fatal. In most cases, no direct cause of cjd can be established.